英文名字 HSP70 Antibody: HRP
中文名称 热休克蛋白70抗体:偶联HRP
供应商 StressMarq
产品货号 SMC-100B-HRP
产品报价 ¥5913.6/200ug
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产品新闻
背景资料 HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity (2). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When HSC70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (4). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (5).
All HSP70s, regardless of location, bind proteins, particularly unfolded ones. The molecular chaperones of the HSP70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding. The binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (6). The universal ability of HSP70s to undergo cycles of binding to and release from hydrophobic stretches of partially unfolded proteins determines their role in a great variety of vital intracellular functions such as protein synthesis, protein folding and oligomerization and protein transport. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide atHSP70.
应用类型 WB | IHC | ICC/IF | ELISA | FCM | FACS | IEM | Bl
免疫原 人 Hsp70
来源宿主 小鼠
反应性 人 | 小鼠 | 大鼠 | 牛 | 秀丽线虫 | 狗 | 鸡 | 果蝇 | 鲤鱼 | 豚鼠 | 仓鼠 | 猴 | 猪 | 兔 | 绵羊
保存建议 厂家推荐蓝冰运输。收到产品后建议保存于-20篊。
产品说明书
其他 StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚,是一家生物科技公司,专门从事试剂与试剂盒研究,服务范围遍及全球50多个国家。 StressMarq公司的核心技术领域为细胞应激(尤其是热休克蛋白(HSP)领域,领先全球),离子通道,载体研究,同时在神经科学领域推出特有的具有生物活性的Tau蛋白与a-突触核蛋白。产品领域涉及到:细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外,StressMarq还提供全新的尖端研究工具,用于开发新的生物项目,包括全球独一无二的a B晶体蛋白ELISA试剂盒(现在是公认的乳腺癌标志物);热休克同源蛋白70(Hsc70)ELISA试剂盒;以及用于神经衰退研究的Tau活性蛋白与a-突触核蛋白。本公司已将专业技术扩展到抗体、小分子离子通道与载体等更新领域,前者包括当前热门的核心领域:Nav、Cav、TRP、Kv、KCNQ、HCN,后者包括当前热门的核心领域:ENaC、NCC和NKCC2以及主要水通道蛋白载体。

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